総合検査のご案内

ALL ROUND INSPECTION GUIDE

日本人集団におけるHLA遺伝子頻度と対応抗原
 



















A Locus
B Locus
B Locus (続き)
DRB1
抗原アリル頻度1頻度2抗原アリル頻度1頻度2抗原アリル頻度1頻度2抗原アリル頻度3頻度2
A-1A01:010.2%0.25%B-7B07:025.2%5.70%B-60B40:07vrvrDR-1DRB101:014.76%5.60%
A-2A02:0110.9%11.64%B-7B07:05B-61B40:29vrvrDR-17DRB103:010.22%0.05%
A-2A02:03r0.10%B-8B08:01B-41B41:01DR-18DRB103:02
A-2A02:0610.4%8.74%B-13B13:010.9%1.28%B-42B42:01DR-4DRB104:011.16%1.28%
A-2A02:073.4%3.39%B-13B13:020.1%0.25%B-44B44:021.0%0.34%DR-4DRB104:033.00%3.00%
A-2A02:100.1%0.44%B-64B14:01/54rrB-44B44:036.9%6.24%DR-4DRB104:040.22%0.34%
NullA02:15NvrvrB-62B15:017.2%7.51%B-45B45:01DR-4DRB104:0515.51%14.05%
A-2A02:18r0.05%B-75B15:02r0.05%B-46B46:013.8%4.96%DR-4DRB104:063.22%3.49%
A02:28rrB-72B15:03rrB-46B46:02vrvrDR-4DRB104:070.44%0.49%
A-2A02:42vrvrB-62B15:05vr0.05%B-47B47:01DR-4DRB104:101.82%1.82%
A-3A03:010.8%0.25%B-62B15:070.7%0.44%B-48B48:012.7%2.65%DR-7DRB107:010.81%0.20%
A-3A03:02r0.10%B-70B15:09vrvrB-49B49:01DR-8DRB108:024.99%4.91%
A-11A11:018.1%10.22%B-75B15:111.0%0.83%B-50B50:01DR-8DRB108:037.55%9.43%
A-11A11:020.1%0.25%B-71B15:180.9%1.72%B-51B51:017.9%8.35%DR-8DRB108:09r0.05%
A-23A23:01NullB15:26NvrvrB-51B51:020.1%0.29%DR-9DRB109:0112.38%14.88%
A-24A24:0235.6%36.20%B-62B15:27vr0.29%B-51B51:03vrvrDR-10DRB110:010.59%0.39%
A-24A24:04r0.15%B-62B15:28r0.05%B-52B52:0113.7%10.90%DR-11DRB111:012.94%2.80%
A-24A24:08rr-B15:38rrB-53B53:01DR-12DRB112:013.90%3.59%
A-24A24:20r0.83%B-72B15:46vrvrB-54B54:016.5%8.79%DR-12DRB112:022.66%1.72%
A-25A25:01-B15:60vrvrB-54B54:02vrvrDR-13DRB113:010.86%0.44%
A-26A26:019.8%7.66%B-18B18:01B-55B55:023.2%1.92%DR-13DRB113:025.25%6.43%
A-26A26:022.2%2.31&B-27B27:02vrvrB-55B55:04r0.05%DR-13DRB113:070.11%0.10%
A-26A26:032.1%1.47%B-27B27:04r0.20%B-55B55:10vrvrDR-13DRB113:12vr0.05%
A-26A26:04vrvrB-27B27:05r0.05%B-56B56:011.0%1.47%DR-14DRB114:02r0.05%
A-26A26:05r0.05%B-27B27:11vrvrB-22B56:030.2%0.05%DR-14DRB114:031.57%1.28%
A-26A26:06vrvrB-35B35:018.6%7.76%B-56B56:05vrvrDR-14DRB114:052.56%2.16%
NullA26:11NvrvrB-35B35:05vr0.05%B-57B57:010.1%rDR-14DRB114:061.36%1.28%
A-29A29:01vrvrB-35B35:10vrvrB-58B58:010.6%0.49%DR-14DRB114:070.27%0.10%
A-30A30:010.3%0.10%B-35B35:21vrvrB-59B59:011.7%1.96%DR-14DRB114:12r0.05%
A-30A30:04vrvrB-35B35:35vrvrB-67B67:011.0%1.38%DR-14DRB114:29rr
A-31A31:017.7%9.14%B-35B35:43vrvrB-78B78:02vrvrDR-14DRB114:544.45%3.83%
A-31A31:05vrvrB-37B37:010.2%0.44%B-81B81:01vrvrDR-15DRB115:016.08%5.75%
A-32A32:01vrvrB-38B38:020.3%0.25%
DR-15DRB115:028.74%9.87%
A-33A33:037.9%6.68%B-39B39:014.0%3.44%DR-16DRB116:020.55%0.54%
A-34A34:01vrvrB-39B39:020.2%0.39%
A-36A36:01B-39B39:040.2%0.20%
A-43A43:01B-39B39:23r0.05%
A-66A66:01B-60B40:015.1%5.40%
A-68A68:01rrB-61B40:028.2%8.25%
A-69A69:01B-61B40:031.1%0.25%
A-74A74:01B-61B40:065.3%5.26%

頻度1:Tanaka H,et al.:Clinical Transplants:139,1996.による日本人N=493のアリル頻度
頻度2:Azuma F,et al.:MHC:166,2004.発表資料による日本人N=1018のアリル頻度
頻度3:Hashimoto M,et al.:Tissue Antigens:166,1994.による日本人N=916のアリル頻度
その他、低頻度により上記の調査で検出されなかったアリルを「rare」とし、さらに低頻度と思われるものを「very rare」とした。
r:rare
vr:very rare
-:日本人に検出されないアリル

日本組織適合性学会ホームページより抜粋
監修:東海大学 医学部 基礎医学系 分子生命科学
教授 猪子 英俊
HLA型の種類
 
 
 
 
 
 
 
 
 
 
A Locus
B Locus
DR Locus
A-1A-30 (19)B-7B-38 (16)B-52 (5)B-65 (14)DR-1DR-10
A-2A-31 (19)B-8B-39 (16)B-53B-67DR-2DR-11 (5)
A-3A-32 (19)B-12B-40B-54 (22)B-70DR-3DR-12 (5)
A-9A-33 (19)B-13B-41B-55 (22)B-71 (70)DR-4DR-13 (6)
A-10A-34 (10)B-14B-42B-56 (22)B-72 (70)DR-5DR-14 (6)
A-11A-36B-15B-44 (12)B-57 (17)B-73DR-6DR-15 (2)
A-23 (9)A-43B-16B-45 (12)B-58 (17)B-75 (15)DR-7DR-16 (2)
A-24 (9)A-66 (10)B-18B-46B-59B-76 (15)DR-8DR-17 (3)
A-25 (10)A-68 (28)B-21B-47B-60 (40)B-77 (15)DR-9DR-18 (3)
A-26 (10)A-69 (28)B-22B-48B-61 (40)B-78
A-28A-74 (19)B-27B-49 (21)B-62 (15)B-81
A-29 (19)A-80B-35B-50 (21)B-63 (15)

B-37B-51 (5)B-64 (14)
●「Nomenclature for factor of HLA system 2004」より抜粋