| 日本人集団におけるHLA遺伝子頻度と対応抗原 | |||||||||||||||||||
| | | | | | | | | | | | | | | | | | | | |
| A Locus | | B Locus | | B Locus (続き) | | DRB1 | |||||||||||||
| 抗原 | アリル | 頻度1 | 頻度2 | 抗原 | アリル | 頻度1 | 頻度2 | 抗原 | アリル | 頻度1 | 頻度2 | 抗原 | アリル | 頻度3 | 頻度2 | ||||
| A-1 | A*01:01 | 0.2% | 0.25% | B-7 | B*07:02 | 5.2% | 5.70% | B-60 | B*40:07 | vr | vr | DR-1 | DRB1*01:01 | 4.76% | 5.60% | ||||
| A-2 | A*02:01 | 10.9% | 11.64% | B-7 | B*07:05 | r | r | B-61 | B*40:29 | vr | vr | DR-17 | DRB1*03:01 | 0.22% | 0.05% | ||||
| A-2 | A*02:03 | r | 0.10% | B-8 | B*08:01 | - | - | B-41 | B*41:01 | - | - | DR-18 | DRB1*03:02 | - | - | ||||
| A-2 | A*02:06 | 10.4% | 8.74% | B-13 | B*13:01 | 0.9% | 1.28% | B-42 | B*42:01 | - | - | DR-4 | DRB1*04:01 | 1.16% | 1.28% | ||||
| A-2 | A*02:07 | 3.4% | 3.39% | B-13 | B*13:02 | 0.1% | 0.25% | B-44 | B*44:02 | 1.0% | 0.34% | DR-4 | DRB1*04:03 | 3.00% | 3.00% | ||||
| A-2 | A*02:10 | 0.1% | 0.44% | B-64 | B*14:01/54 | r | r | B-44 | B*44:03 | 6.9% | 6.24% | DR-4 | DRB1*04:04 | 0.22% | 0.34% | ||||
| Null | A*02:15N | vr | vr | B-62 | B*15:01 | 7.2% | 7.51% | B-45 | B*45:01 | - | - | DR-4 | DRB1*04:05 | 15.51% | 14.05% | ||||
| A-2 | A*02:18 | r | 0.05% | B-75 | B*15:02 | r | 0.05% | B-46 | B*46:01 | 3.8% | 4.96% | DR-4 | DRB1*04:06 | 3.22% | 3.49% | ||||
| - | A*02:28 | r | r | B-72 | B*15:03 | r | r | B-46 | B*46:02 | vr | vr | DR-4 | DRB1*04:07 | 0.44% | 0.49% | ||||
| A-2 | A*02:42 | vr | vr | B-62 | B*15:05 | vr | 0.05% | B-47 | B*47:01 | - | - | DR-4 | DRB1*04:10 | 1.82% | 1.82% | ||||
| A-3 | A*03:01 | 0.8% | 0.25% | B-62 | B*15:07 | 0.7% | 0.44% | B-48 | B*48:01 | 2.7% | 2.65% | DR-7 | DRB1*07:01 | 0.81% | 0.20% | ||||
| A-3 | A*03:02 | r | 0.10% | B-70 | B*15:09 | vr | vr | B-49 | B*49:01 | - | - | DR-8 | DRB1*08:02 | 4.99% | 4.91% | ||||
| A-11 | A*11:01 | 8.1% | 10.22% | B-75 | B*15:11 | 1.0% | 0.83% | B-50 | B*50:01 | - | - | DR-8 | DRB1*08:03 | 7.55% | 9.43% | ||||
| A-11 | A*11:02 | 0.1% | 0.25% | B-71 | B*15:18 | 0.9% | 1.72% | B-51 | B*51:01 | 7.9% | 8.35% | DR-8 | DRB1*08:09 | r | 0.05% | ||||
| A-23 | A*23:01 | - | - | Null | B*15:26N | vr | vr | B-51 | B*51:02 | 0.1% | 0.29% | DR-9 | DRB1*09:01 | 12.38% | 14.88% | ||||
| A-24 | A*24:02 | 35.6% | 36.20% | B-62 | B*15:27 | vr | 0.29% | B-51 | B*51:03 | vr | vr | DR-10 | DRB1*10:01 | 0.59% | 0.39% | ||||
| A-24 | A*24:04 | r | 0.15% | B-62 | B*15:28 | r | 0.05% | B-52 | B*52:01 | 13.7% | 10.90% | DR-11 | DRB1*11:01 | 2.94% | 2.80% | ||||
| A-24 | A*24:08 | r | r | - | B*15:38 | r | r | B-53 | B*53:01 | - | - | DR-12 | DRB1*12:01 | 3.90% | 3.59% | ||||
| A-24 | A*24:20 | r | 0.83% | B-72 | B*15:46 | vr | vr | B-54 | B*54:01 | 6.5% | 8.79% | DR-12 | DRB1*12:02 | 2.66% | 1.72% | ||||
| A-25 | A*25:01 | - | - | - | B*15:60 | vr | vr | B-54 | B*54:02 | vr | vr | DR-13 | DRB1*13:01 | 0.86% | 0.44% | ||||
| A-26 | A*26:01 | 9.8% | 7.66% | B-18 | B*18:01 | - | - | B-55 | B*55:02 | 3.2% | 1.92% | DR-13 | DRB1*13:02 | 5.25% | 6.43% | ||||
| A-26 | A*26:02 | 2.2% | 2.31& | B-27 | B*27:02 | vr | vr | B-55 | B*55:04 | r | 0.05% | DR-13 | DRB1*13:07 | 0.11% | 0.10% | ||||
| A-26 | A*26:03 | 2.1% | 1.47% | B-27 | B*27:04 | r | 0.20% | B-55 | B*55:10 | vr | vr | DR-13 | DRB1*13:12 | vr | 0.05% | ||||
| A-26 | A*26:04 | vr | vr | B-27 | B*27:05 | r | 0.05% | B-56 | B*56:01 | 1.0% | 1.47% | DR-14 | DRB1*14:02 | r | 0.05% | ||||
| A-26 | A*26:05 | r | 0.05% | B-27 | B*27:11 | vr | vr | B-22 | B*56:03 | 0.2% | 0.05% | DR-14 | DRB1*14:03 | 1.57% | 1.28% | ||||
| A-26 | A*26:06 | vr | vr | B-35 | B*35:01 | 8.6% | 7.76% | B-56 | B*56:05 | vr | vr | DR-14 | DRB1*14:05 | 2.56% | 2.16% | ||||
| Null | A*26:11N | vr | vr | B-35 | B*35:05 | vr | 0.05% | B-57 | B*57:01 | 0.1% | r | DR-14 | DRB1*14:06 | 1.36% | 1.28% | ||||
| A-29 | A*29:01 | vr | vr | B-35 | B*35:10 | vr | vr | B-58 | B*58:01 | 0.6% | 0.49% | DR-14 | DRB1*14:07 | 0.27% | 0.10% | ||||
| A-30 | A*30:01 | 0.3% | 0.10% | B-35 | B*35:21 | vr | vr | B-59 | B*59:01 | 1.7% | 1.96% | DR-14 | DRB1*14:12 | r | 0.05% | ||||
| A-30 | A*30:04 | vr | vr | B-35 | B*35:35 | vr | vr | B-67 | B*67:01 | 1.0% | 1.38% | DR-14 | DRB1*14:29 | r | r | ||||
| A-31 | A*31:01 | 7.7% | 9.14% | B-35 | B*35:43 | vr | vr | B-78 | B*78:02 | vr | vr | DR-14 | DRB1*14:54 | 4.45% | 3.83% | ||||
| A-31 | A*31:05 | vr | vr | B-37 | B*37:01 | 0.2% | 0.44% | B-81 | B*81:01 | vr | vr | DR-15 | DRB1*15:01 | 6.08% | 5.75% | ||||
| A-32 | A*32:01 | vr | vr | B-38 | B*38:02 | 0.3% | 0.25% | | DR-15 | DRB1*15:02 | 8.74% | 9.87% | |||||||
| A-33 | A*33:03 | 7.9% | 6.68% | B-39 | B*39:01 | 4.0% | 3.44% | DR-16 | DRB1*16:02 | 0.55% | 0.54% | ||||||||
| A-34 | A*34:01 | vr | vr | B-39 | B*39:02 | 0.2% | 0.39% | | |||||||||||
| A-36 | A*36:01 | - | - | B-39 | B*39:04 | 0.2% | 0.20% | ||||||||||||
| A-43 | A*43:01 | - | - | B-39 | B*39:23 | r | 0.05% | ||||||||||||
| A-66 | A*66:01 | - | - | B-60 | B*40:01 | 5.1% | 5.40% | ||||||||||||
| A-68 | A*68:01 | r | r | B-61 | B*40:02 | 8.2% | 8.25% | ||||||||||||
| A-69 | A*69:01 | - | - | B-61 | B*40:03 | 1.1% | 0.25% | ||||||||||||
| A-74 | A*74:01 | - | - | B-61 | B*40:06 | 5.3% | 5.26% | ||||||||||||
| | |||||||||||||||||||
| 頻度1:Tanaka H,et al.:Clinical Transplants:139,1996.による日本人N=493のアリル頻度 | |||||||||||||||||||
| 頻度2:Azuma F,et al.:MHC:166,2004.発表資料による日本人N=1018のアリル頻度 | |||||||||||||||||||
| 頻度3:Hashimoto M,et al.:Tissue Antigens:166,1994.による日本人N=916のアリル頻度 | |||||||||||||||||||
| その他、低頻度により上記の調査で検出されなかったアリルを「rare」とし、さらに低頻度と思われるものを「very rare」とした。 | |||||||||||||||||||
| r:rare | |||||||||||||||||||
| vr:very rare | |||||||||||||||||||
| -:日本人に検出されないアリル | |||||||||||||||||||
| | |||||||||||||||||||
| 日本組織適合性学会ホームページより抜粋 監修:東海大学 医学部 基礎医学系 分子生命科学 教授 猪子 英俊 | |||||||||||||||||||
| HLA型の種類 | |||||||||
| | | | | | | | | | |
| A Locus | | B Locus | | DR Locus | |||||
| A-1 | A-30 (19) | B-7 | B-38 (16) | B-52 (5) | B-65 (14) | DR-1 | DR-10 | ||
| A-2 | A-31 (19) | B-8 | B-39 (16) | B-53 | B-67 | DR-2 | DR-11 (5) | ||
| A-3 | A-32 (19) | B-12 | B-40 | B-54 (22) | B-70 | DR-3 | DR-12 (5) | ||
| A-9 | A-33 (19) | B-13 | B-41 | B-55 (22) | B-71 (70) | DR-4 | DR-13 (6) | ||
| A-10 | A-34 (10) | B-14 | B-42 | B-56 (22) | B-72 (70) | DR-5 | DR-14 (6) | ||
| A-11 | A-36 | B-15 | B-44 (12) | B-57 (17) | B-73 | DR-6 | DR-15 (2) | ||
| A-23 (9) | A-43 | B-16 | B-45 (12) | B-58 (17) | B-75 (15) | DR-7 | DR-16 (2) | ||
| A-24 (9) | A-66 (10) | B-18 | B-46 | B-59 | B-76 (15) | DR-8 | DR-17 (3) | ||
| A-25 (10) | A-68 (28) | B-21 | B-47 | B-60 (40) | B-77 (15) | DR-9 | DR-18 (3) | ||
| A-26 (10) | A-69 (28) | B-22 | B-48 | B-61 (40) | B-78 | | |||
| A-28 | A-74 (19) | B-27 | B-49 (21) | B-62 (15) | B-81 | ||||
| A-29 (19) | A-80 | B-35 | B-50 (21) | B-63 (15) | | ||||
| | B-37 | B-51 (5) | B-64 (14) | ||||||
| ●「Nomenclature for factor of HLA system 2004」より抜粋 | |||||||||